FILMS  

Our films are about the size of a postage stamp and can deliver therapeutic actives through the oral mucosal tissue, sublingually or buccally – between the cheek and gum – or more traditionally via the gastrointestinal tract. Oral transmucosal drug delivery is a non-invasive route reserved for pharmaceutical drugs that allows for absorption directly into the vascularized tissue in the mouth, bypassing the hepatic first pass effect. This leads to reduced drug exposure and can offer a rapid onset of action.

Active ingredients in the film dose form can be either pre-solubilized within its matrix or encapsulated, or both for more effective absorption and/or sustained release. As oral thin films quickly dissolve, no water is required for their administration, improving patient compliance – especially among the elderly, children, and in conditions where patients have difficulty in swallowing.

Advantages of Vobis Films:

Ease of use - melt in your mouth; no need for water, swallowing or chewing

Immediate - buccal absorption - absorbed directly into tissue in the mouth and into the bloodstream

Fast acting - potential for faster onset, clinical effect and symptom relief

Deliver actives through the oral mucosal tissue either sublingually or buccally

Noninvasive

Actives can be encapsulated or pre-solubilized within the film matrix

High load:  direct multiple actives that are stable at room temperature

Precision dosing: uniform distribution allows for precision dosing

Decreased risk:  potential for reduced side effects with a lower dose

Suitable for both pharmaceuticals and wellness products (per oral only)

Active Loads:

Multiple actives up to 200 mg

Stable at room temperature for most active ingredients

CHEWABLE PODS

Chewable or dissolvable pods of over an inch in diameter deliver active ingredients in unique envelopes that are formed utilizing our films.

We can develop them for actives release upon chewing or after exposure to saliva digestive or both. Distinct layers may be formed to deliver multiple active ingredients in the same pod, with distinct release profiles if needed. They are designed to be pleasing for an enjoyable experience.

 The mouth feel, dissolution time, and release of active ingredients can be modulated by altering the excipient ratios.

Advantages of Pods

• Simultaneously load fat soluble and water-soluble molecules

• Overcome problems with poorly soluble and poorly absorbed nutrients

• Multiple shapes, sizes, flavors, and colors

• High doses of actives (grams)

• Ideal for sports wellness products

Spray Drying

Vobis offers Open Loop for water and Closed Loop Spray Drying for solvents beginning with Buchi scale glass trials.

Our team can provide formulation consultation and R&D programs for custom proprietary ingredients and private labelling.

Beginning with preliminary small scale proof of concept formulation development, small samples are produced.

We provide contract formulation development for delivery systems applications including:

• cGMP pharma, food, nutra or industrial

• Controlled, sustained, and immediate release

• Actives protection

• Taste and odor masking

We specialize in converting oil-based actives into bioavailable powders or liquids:

• Water based formulations of oil-based actives begins by incorporating stabilizing ingredients

• Fat soluble active ingredients are incorporated into water-based liquids or powders using various micro-emulsification techniques for improved bioavailability as well as stability

• Final forms include liquid concentrates, beverages, and powders in stick packs

• The result is water-based powders, solutions delivering fat-soluble active ingredients

Pilot scale testing is completed to enable production system design and implementation.

LIPOSOMES

Liposomal encapsulation experience particularly specific to lipid-based nanoparticles with encapsulation of variety of payloads including small molecules and nucleic acids (plasmid DNA, siRNA and ASO). 

We have developed proprietary lipid based nano technologies that have potential benefits in different therapeutic areas including targeted cancer therapy, DNA Vaccination and liver diseases.
Here are the some of the highlights related to our LNP and liposomal experience including type of liposomes and techniques.  

Types of Liposomes

Conventional liposomes: The lipid layer of liposomes is negatively and positively charged phospholipids and cholesterol, which are attached to aqueous core. The bilayer of lipid and the aqueous penetrate through the hydrophobic and hydrophilic compounds, respectively.
pH-sensitive liposomes: The lipid composition of liposomes, destabilize when the external pH changes from a neutral or alkaline to an acidic state.
Cationic liposomes: The liposome contains one positive (cationic) charged (phospho)lipid. It interacts with negatively charged compounds or nucleic acids at the time of a simple mixing process.
Immuno liposomes: The liposomes contain antibody molecules or substances in the liposomal surface.
Long circulating liposomes: The hydrophilic layer of oligosaccharides, glycoproteins, polysaccharides and synthetic polymers are coated to the liposome surface, which helps to allow the prolonged circulation of the liposomal material in drug delivery systems.

Techniques involved in liposome microencapsulation

Passive loading techniques

• Mechanical dispersion method
  Lipid film hydration 
  Micro emulsification 
  Membrane extrusion 

• Solvent dispersion method
  Ethanol or ether injection 
  Double emulsion 
  Reverse phase evaporation vesicles 

• Detergent removal technique
  Dialysis 
  Gel permeation chromatography 
  Diffusion 

Active loading techniques
Citrate method 
Ammonium sulfate method 
Ionophore generated pH gradient method